COPEGUS, ribavirin, is a nucleoside analog with antiviral activity. Ribavirin has direct antiviral activity in tissue culture against many RNA viruses. Ribavirin increases the mutation frequency in the genomes of several viruses and ribavirin triphosphate inhibits HCV polymerase in a biochemical reaction. It is used as an adjuvant therapy for Hepatitis C with a number of benefits to the patient:

• Suitable for adjuvant therapy in Hepatitis c patients
• Ensures high sustained virologic response
• Improves liver histology

This solid-solid dispersion technology of Ledipasvir ensures faster dissolution rate compared to crystalline form.

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